Current Crosslistings BIOC 5403
BIOC 5403
BIOC 3400
Distinguish between gene activation and gene repression. [BIOC 4404] Describe the physical and chemical structure of the human genome, and provide examples of technologies currently used to elucidate and manipulate its content. [BIOC 1040] Outline in some molecular detail the processes by which genetic information is replicated and expressed, leading to protein synthesis, targeting and turnover. [BIOC 1040] Distinguish between RNA dependent and DNA dependent Polymerases and identify the process where they are involved. [BIOC 3400] Identify/recognize and explain the roles of the major proteins involved in the process of DNA replication/RNA synthesis and its regulation. [BIOC 3400]
Compare representative mitochondrial genomes (human, plants, algae) in terms of gene content, organization, and expression.Identify and distinguish intervening sequences (group I introns, group II introns, twintrons, split intron, inteins), using key structural and mechanistic features.Identify key evidences/arguments for hypothesis on the origin/evolution of genes from an RNA world.Interpret features of bacterial genome organization: non-random positioning and orientation of certain genes in relationship to overlapping rounds of genome replication.Interpret plasmid maintenance and evolution in terms of plasmid genes (poison-antidote mechanism).Compare mobile genetic elements (DNA transposons, retrotransposons) as drivers of genome evolution.Interpret genetic mobility of introns and inteins, by comparing mechanisms of intron/intein homing and transposition.Interpret roles of DNA methylation in genome evolution (CpG islands) and gene regulation (epigenetics).Recall DNA replication, transcription, and RNA processing.Given hypothesis on the origin of nuclear genome (composite nature) and organelle genomes (endosymbiosis), identify key evidences and arguments.Identify steps and mechanisms of evolutionary gene transfer from organelle genomes to nuclear genome.Compare different types and mechanisms of RNA editing and translational recoding.Compare different techniques of next generation DNA sequencing in terms of advantages/disadvantages and fields of application.Interpret roles of alternative RNA splicing in expansion of the proteome.
