BIOC 3300BIOC 3400BIOC 3700
Describe the basic principles of intracellular signal transduction and discuss how these processes may alter gene expression, protein function and cellular fate. [BIOC 1040] [BIOC 2300] Recognize high energy intermediates and their role in reaction energetics: substrate level phosphorylation. [BIOC 3300] Describe the physical and chemical structure of the human genome, and provide examples of technologies currently used to elucidate and manipulate its content. [BIOC 1040] Determine the effects of loss of function or gain of function mutations of regulating enzymes or metabolic enzymes on the rate of a reaction given a schematic of enzyme regulation. [BIOC 2300] Recall basic principles of regulation of anabolic and catabolic pathways in biochemistry. [BIOC 3300] Explain the contribution of DNA packaging/chromatin to gene expression and regulation. [BIOC 3400]
Distinguish between receptor/non-receptor kinases.Distinguish between tumour suppressor and oncogene activity.Understand angiogenesis.Understand the concept of apoptosis.Distinguish the regulators of cell cycle.Understand the concept of signal transduction.Distinguish between normal and abnormal cell signalling.Distinguish relevant signalling domains.Distinguish the lipids involved in signal transduction.Understand genomic stability versus instability.Understand loss of function versus gain of function mutations.Understand the concept of phosphorylation-mediated signal transduction.Understand the phases of cell cycle.Understand cell migration.Distinguish between cell migration and metastasis.Understand autophagy.Understand chromatin remodelling.
