Current Crosslistings BIOC 5010
BIOC 5010
BIOC 3400
Identify and distinguish intervening sequences (group I introns, group II introns, twintrons, split intron, inteins), using key structural and mechanistic features. [BIOC 4403] Interpret features of bacterial genome organization: non-random positioning and orientation of certain genes in relationship to overlapping rounds of genome replication. [BIOC 4403] Understand the principles of bioenergetics, including the implications of free energy change occurring in a chemical reaction. [BIOC 2300] Describe and interrelate the hierarchical levels of protein structure (1˚ to 4˚) and provide examples of how this structure relates to the function (or dysfunction) of various classes of proteins. [BIOC 1040] [BIOC 2300] Understand the established principles of protein folding. [BIOC 4700] Explain the biophysics of the non-covalent forces and kinetics and mechanisms governing protein folding and stability. [BIOC 4700]
Compare two classifiers based on their performances.Explain what a Python script does using a combination of read, write and file operations.Explain what is a Hamiltonian/Eulerian path and what it means to the genome assembly problem.Explain what is an algorithm.Explain why structural alignment is the “ground truth” for a sequence alignment.Explain why the quality of a simulation is more dependent on the speed of a calculation rather than its accuracy.Relate the concept of accuracy with this of specificity, sensitivity and F-score.Contrast the challenge of finding exons versus finding ORFs.Explain the Greedy method of genome assembly and its limitations.Explain where the OLC/Eulerian_path algorithm may fail to give the correct genomic sequence.Explain why ab initio protein folding, or the prediction of tertiary structure from a sequence, is considered one of the most challenging problems in computational biology.Explain the problems related to the parametrization of Force Fields.Distinguish Force Field and statistical mechanics energies.
