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B. Sc. Biochemistry & Molecular Biology
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#sequence
Explain why structural alignment is the “ground truth” for a sequence alignment.
[
BIOC 4010
]
Identify and distinguish intervening sequences (group I introns, group II introns, twintrons, split intron, inteins), using key structural and mechanistic features.
[
BIOC 4403
]
Explain where the OLC/Eulerian_path algorithm may fail to give the correct genomic sequence.
[
BIOC 4010
]
Explain why ab initio protein folding, or the prediction of tertiary structure from a sequence, is considered one of the most challenging problems in computational biology.
[
BIOC 4010
]
Given DNA sequence data design (probes), recognize their use in different techniques such as PCR, microarray, southern blotting.
[
BIOC 3400
]
Predict the fate of a protein based on features of the primary sequence.
[
BIOC 3400
]
Explain the molecular basis of procedures such as gene cloning, cDNA and genomic DNA library screening, polymerase chain reaction (PCR) amplification of DNA, DNA sequencing, microarray technology, nuclear transfer somatic cell and induced pluripotent stem cell cloning, gene therapy.
[
BIOC 4501
]
Explain the process of chain termination DNA sequencing.
[
BIOC 3400
]
Explain the processing (splicing, editing) of RNA (mRNA, tRNA, rRNA). Predict the effects of mutations in the primary RNA sequence.
[
BIOC 3400
]
Given a DNA sequence and restriction enzyme data, analyze a band pattern in a gel and generate a restriction map.
[
BIOC 3400
]
Compare different techniques of next generation DNA sequencing in terms of advantages/disadvantages and fields of application.
[
BIOC 4403
]
Identify the different types of DNA and RNA sequence elements regulating eukaryotic gene expression.
[
BIOC 4404
]
Predict the mRNA and the amino acid sequence given a DNA sequence.
[
BIOC 3400
]
Explain how different types of DNA and RNA sequence elements are involved regulating eukaryotic gene expression.
[
BIOC 4404
]
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