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B. Sc. Biochemistry & Molecular Biology
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#mechanism
Analyze optical spectra (absorption, emission, fluorescence anisotropy, LD, CD, IR, Raman) with respect to polypeptide structure and environment and with relation to quantum mechanical basis of a given spectroscopic technique.
[
BIOC 4702
]
Discuss the necessity of protein turnover within cells and organisms and the degradative and regulatory mechanisms that govern protein turnover.
[
BIOC 4700
]
Draw energy level diagrams showing the quantum mechanical basis of electronic absorption and emission spectroscopy with specific reference to the Franck-Condon principle.
[
BIOC 4702
]
Explain regulation exerted by different mechanisms of translational control.
[
BIOC 4404
]
Given a pH-dependent kinetic mechanism, derive an initial velocity equation and sketch the plot of kinetic constants as a function of pH.
[
BIOC 4701
]
Given the architecture of an enzyme active site, write a mechanism and show how general acid/base, covalent, or electrophilic catalysis may occur.
[
BIOC 3700
]
Given the kinetic mechanism (with or without inhibition), derive an initial velocity equation using either the steady-state assumption or the rapid equilibrium approach.
[
multiple courses
]
Identify and distinguish intervening sequences (group I introns, group II introns, twintrons, split intron, inteins), using key structural and mechanistic features.
[
BIOC 4403
]
Interpret plasmid maintenance and evolution in terms of plasmid genes (poison-antidote mechanism).
[
BIOC 4403
]
Interpret genetic mobility of introns and inteins, by comparing mechanisms of intron/intein homing and transposition.
[
BIOC 4403
]
Analyze the detailed mechanism for the generation of the proton motive force across bioenergetic membranes.
[
BIOC 4700
]
Classify different regulatory mechanisms of gene transcription.
[
BIOC 4404
]
Derive the steady-state velocity equation for a given kinetic mechanism for a multisubstrate enzyme using the King-Altman method.
[
BIOC 4701
]
Given the substrates, products, and cofactors for a particular class of enzyme-catalyzed reaction, write a mechanism for the reaction.
[
BIOC 3700
]
Recognize the main mechanism of action of insulin and/or glucagon and their pathways.
[
BIOC 2300
]
Explain the biophysics of the non-covalent forces and kinetics and mechanisms governing protein folding and stability.
[
BIOC 4700
]
Given an enzyme mechanism, design a reversible or irreversible inhibitor.
[
multiple courses
]
Identify steps and mechanisms of evolutionary gene transfer from organelle genomes to nuclear genome.
[
BIOC 4403
]
Explain how lipids form membranes and lipoproteins and influence their function, and list different transport mechanisms across membranes.
[
BIOC 2300
]
Compare different types and mechanisms of RNA editing and translational recoding.
[
BIOC 4403
]
Describe cellular mechanisms of transport that enable the cell to maintain membrane asymmetry and the cellular distribution of lipids.
[
BIOC 3300
]
Distinguish Force Field and statistical mechanics energies.
[
BIOC 4010
]
Given a type of DNA damage explain the repair mechanisms that can occur.
[
BIOC 3400
]
Distinguish among various mechanisms for the modulation of chromatin effects.
[
BIOC 4404
]
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