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B. Sc. Biochemistry & Molecular Biology
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#genome
Explain what is a Hamiltonian/Eulerian path and what it means to the genome assembly problem.
[
BIOC 4010
]
Identify and distinguish intervening sequences (group I introns, group II introns, twintrons, split intron, inteins), using key structural and mechanistic features.
[
BIOC 4403
]
Interpret features of bacterial genome organization: non-random positioning and orientation of certain genes in relationship to overlapping rounds of genome replication.
[
BIOC 4403
]
Compare mobile genetic elements (DNA transposons, retrotransposons) as drivers of genome evolution.
[
BIOC 4403
]
Contrast the challenge of finding exons versus finding ORFs.
[
BIOC 4010
]
Describe the physical and chemical structure of the human genome, and provide examples of technologies currently used to elucidate and manipulate its content.
[
BIOC 1040
]
Explain the Greedy method of genome assembly and its limitations.
[
BIOC 4010
]
Interpret genetic mobility of introns and inteins, by comparing mechanisms of intron/intein homing and transposition.
[
BIOC 4403
]
Interpret roles of DNA methylation in genome evolution (CpG islands) and gene regulation (epigenetics).
[
BIOC 4403
]
Explain where the OLC/Eulerian_path algorithm may fail to give the correct genomic sequence.
[
BIOC 4010
]
Given hypothesis on the origin of nuclear genome (composite nature) and organelle genomes (endosymbiosis), identify key evidences and arguments.
[
BIOC 4403
]
Understand genomic stability versus instability.
[
BIOC 4305
]
Identify steps and mechanisms of evolutionary gene transfer from organelle genomes to nuclear genome.
[
BIOC 4403
]
Explain the molecular basis of procedures such as gene cloning, cDNA and genomic DNA library screening, polymerase chain reaction (PCR) amplification of DNA, DNA sequencing, microarray technology, nuclear transfer somatic cell and induced pluripotent stem cell cloning, gene therapy.
[
BIOC 4501
]
Distinguish the differences between prokaryotes and eukaryotes in terms of genome organization, gene structure, and expression and DNA replication.
[
BIOC 3400
]
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