• Apply fundamental principles of chemistry and physics (e.g. molecular bonding, thermodynamics, kinetics) to explain important concepts in biochemistry.
  • Demonstrate basic skills in a biochemistry laboratory, including the awareness of chemical and biological safety, the practice of experimental technique, and the recording, interpretation and written communication of laboratory observations.
  • Describe the basic principles of intracellular signal transduction and discuss how these processes may alter gene expression, protein function and cellular fate.
  • Explain how enzymes can increase the rates of biochemical reactions at the molecular level, and how they may be inhibited or regulated by drugs and toxins.
  • Use the scientific literature and other available resources to research topics in human biochemistry and, in a small group tutorial setting, to answer guided questions and attain learning objectives.
  • Describe the physical and chemical structure of the human genome, and provide examples of technologies currently used to elucidate and manipulate its content.
  • Identify general features of the common classes of biomolecules: carbohydrates, lipids, nucleotides and amino acids.
  • Outline in some molecular detail the processes by which genetic information is replicated and expressed, leading to protein synthesis, targeting and turnover.
  • Describe and interrelate the hierarchical levels of protein structure (1˚ to 4˚) and provide examples of how this structure relates to the function (or dysfunction) of various classes of proteins.
  • Outline the major metabolic pathways by which biomolecules (carbohydrates, lipids, amino acids) are synthesized, degraded and transported, and identify the key points at which these pathways are regulated.
  • Describe how humans obtain, store, and utilize energy through metabolic transformations of biomolecules, and outline the fundamental principles of nutritional balance.
  • Explain how metabolic pathways are controlled to maintain homeostasis of organisms under normal physiological conditions, and give examples of how this may be influenced by nutrition, drugs, and certain pathological states such as diabetes and obesity.
  • List the major macro- and micronutrients essential for human health, and explain their actions at the biochemical level.